[February 21, 2023: Portland, OR] The US Patent and Trademark Office has granted Tricol Biomedical, a global leader in innovating hemostasis and wound care solutions, a new patent (#11,564,673) for the company’s modified chitosan dressing and its through-the-scope delivery in the gastrointestinal (GI) tract to quickly control serious bleeding for up to 96 hours.

The patent – the first of its kind for Tricol Biomedical – will protect intellectual property surrounding this modified chitosan dressing designed to provide easy delivery with prolonged safe and effective use within the GI tract. Tricol’s proprietary chitosan-based hemorrhage control platform, branded as Chito+™, has been demonstrated to control serious bleeding quickly and safely, with excellent maintenance of bleeding control.

“Prolonged bleeding in the upper gastrointestinal tract is a significant problem in the emergency room and in acute care settings,” commented Christopher Rowland, President and CEO of Tricol Biomedical. “This patent, the first in a family of patents, protects a powerful new tool for use in GI hemostasis.”

Recently recognized as a 2022 Top 10 Wound Care Solutions Company, Tricol has been a world leader in advanced acute wound care innovation for more than 20 years and is dedicated to expanding technologies, platforms, and applications to improve and save lives around the world. Through a strong scientific background, highly skilled team, and significant emphasis on research and development, Tricol has established itself as a global hemostasis devices company that continues to innovate and deliver on its mission to achieve zero preventable deaths due to blood loss. The company holds over 60 patents with its technology documented in over 30 clinical publications. Tricol manufacturers its life-saving Chito+™ hemostatic gauze and bandage families but is also focused on future implantable offerings with controlled dissolution, meaning they effectively control bleeding but then are dissolved sufficiently for the body to pass.

New Product Offerings with Strategic Partners Will Expand Access for End Users

[December 13: Portland, OR] Tricol Biomedical, a global leader in innovating hemostasis and wound care solutions, has expanded its GPO agreements to include the OneStop™ Vascular line of procedural care products. In addition, the company has developed an exclusive U.S. distribution agreement with Salvin Dental Specialties for the company’s HemCon^® Dental Dressing PRO product line.

Tricol’s agreements with these and others are part of the company’s strategic vision to provide safe, effective hemostasis solutions for medical interventions in the pre-hospital, trauma, acute care, and non-acute care settings.

The company has added new hemostatic devices to its GPO contracts. Both serve as hospital purchasing partners within the United States for their procedural care product lines. Their agreements will now include the OneStop™ Vascular line (1.5 in, 2 in, and pre-slit) to provide unique, non-invasive solutions to control bleeding quickly and safely in both planned and emergent medical procedures.

Tricol’s agreement with Salvin Dental Specialties enables the distributor to sell – exclusively – Tricol’s HemCon^® Dental Dressing PRO product line, an oral wound dressing intended as a physical barrier for temporary protection of oral mucosal tissue wounds and to provide pain relief to patients.

“Tricol is constantly innovating with our partners to improve the flow of new product offerings, opening the door with these expanded agreements,” said Christopher Rowland, Tricol’s President and CEO. “At Tricol, it’s all about access to our products — whether online, through our direct sales entities, or through our distribution partnerships. With Tricol’s proprietary chitosan platform, marketed as Chito+™, our sales, purchasing, and distribution partners all enjoy carrying medical devices with the highest level of quality and innovation for hemostasis management.”

Recently recognized as a 2022 Top 10 Wound Care Solutions Company, Tricol has been a world leader in advanced acute wound care innovation for more than 20 years and is dedicated to expanding technologies, platforms, and applications to improve and save lives around the world. Through a strong scientific background, highly skilled team, and significant emphasis on research and development, Tricol has established itself as a global hemostasis devices company that continues to innovate and deliver on its mission to achieve zero preventable deaths due to blood loss. The company holds over 60 patents with its technology documented in over 30 clinical publications. Tricol manufacturers its life-saving Chito+™ hemostatic gauze and bandage families but is also focused on future implantable offerings with controlled dissolution, meaning they effectively control bleeding but then are dissolved sufficiently for the body to pass.

Tricol’s Chito+™ Has the Power to Address Hemostasis In and Out of the Hospital

[October 25, 2022: Portland, OR] MedTech Outlook has recognized Tricol Biomedical as a Top Wound Care Solutions provider in its annual Wound Care Solutions issue. The publication, which includes a profile of Tricol, highlights the top ten companies that are advancing the standard of wound care with specialized products that deliver top-quality solutions to patients around the world.

“We are honored to be included on this prestigious list with other groundbreaking companies in the wound care space,” commented Christopher Rowland, Tricol’s President and CEO. “Innovative technologies like Chito+™ – Tricol’s proprietary version of chitosan made from shrimp shells – can be applied to patients in numerous situations when bleeding is an issue – in and out of the hospital – and we are proud to advance patient care globally.”

For more than 20 years, Tricol has been a world leader in advanced acute wound care innovation and is dedicated to expanding technologies, platforms, and applications to improve and save lives around the globe. Through strong scientific background, a highly skilled team, and significant emphasis on research and development, Tricol has established itself as a global hemostasis devices company that continues to innovate and deliver on its mission to achieve zero preventable deaths due to blood loss. The company holds over 60 patents with its technology documented in over 30 clinical publications. Tricol manufacturers its life-saving Chito+™ hemostatic gauze and bandage families but is also focused on future implantable offerings with controlled dissolution, meaning they effectively control bleeding, but then are dissolved sufficiently for the body to pass.

The poster presentation at the Military Health System Research Symposium investigated the use of the ABC compound in an animal study.

[September 29, 2022: Portland, OR] A preclinical study presented at the Military Health System Research Symposium (MHSRS) this month demonstrated that the proprietary^† Absorbable Biocompatible Chitosan (ABC) investigational product from Tricol Biomedical is both absorbable and biocompatible in an internal bleeding rodent model.

The poster presentation, Development of Bioabsorbable Chitosan Hemostatic Wound Dressing by Hua Xie and others, investigated the bioabsorption kinetics and biocompatibility of the ABC dressing when placed intraperitoneally on an injured liver lobe and subcutaneously in 16 animal subjects.

The authors describe the evaluation: “Exsanguinating hemorrhage is the leading cause of death of soldier in wartime and the second leading cause of death in civilian traumatic injuries. Quickly accessing and stabilizing the wound with effective hemostatic techniques is the key for life saving in these events. Historically, HemCon^® chitosan hemostatic dressings (composed of chitosan with degree of deacetylation above 78 percent that is not readily bioabsorbable) were developed to address severe hemorrhage for external applications. In this study an absorbable, biocompatible chitosan (ABC) is prepared with a lower and narrow range of degree of deacetylation to provide a chitosan dressing material with good hemostatic properties that bioabsorbs without biodegradation induced fragmentation, and without adverse cytokine mediated inflammatory responses. The open structure, freeze dried porous matrix ABC dressing of the study is designed to facilitate biodegradation by providing enhanced cellular infiltration and proliferation.”

The results of the preclinical study demonstrated:

• Desirable bioabsorption properties and biocompatibility of the ABC dressing in both subcutaneous and intraperitoneal implantation models.
• The ABC dressing implant was 85% absorbed in 28 days and close to fully absorbed within 60 to 90 days at both implantation sites.
• The ABC chitosan dressing demonstrates absorbable biocompatibility without systemic or local adverse responses.
• The ABC chitosan dressing does not result in surgical adhesion formation greater than Grade 2 – no surgical adhesions were observed.

“The proof of principle within this preclinical study demonstrates a significant potential to address internal bleeding with our mucoadhesive controlled dissolution product line,” commented Christopher Rowland, Tricol’s President and CEO. “Tricol has a long history of innovation and is committed to further progressing technologies that cut across hospital call points, procedures, and specialties to significantly benefit the health of patients around the world.”

For more than 20 years, Tricol has been a world leader in advanced acute wound care innovation and is dedicated to expanding technologies, platforms, and applications to improve and save lives around the globe. Through strong scientific background, a highly skilled team and significant emphasis on research and development, Tricol has established itself as a global medical products company that continues to innovate its initial foundation of advanced hemostatic solutions. The company holds over 60 patents and 32 clinical publications, manufacturing life-saving Chito+™ hemostatic product families like HemCon^® and OneStop^®.

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^† Protected by US 9547011; US 9846163; US9925310; US 10709817; CZ 3003026; DE 602014050166.4; CN105142399

Tricol Biomedical, a privately held medical device company dedicated to saving lives through innovative, hemostatic, and wound care solutions, has received an $853,585 grant from the National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health’s Small Business Technology Transfer (STTR) Program. The Phase IIB grant will support final development of Tricol’s proprietary hemostatic device to address bleeding in prostate-related procedures for treatment of both benign and malignant prostate conditions.

In the U.S. alone, more than 42 million men over the age 50 suffer from Benign Prostatic Hyperplasia (BPH), and roughly 12 million require medical attention and intervention for the condition, often through minimally-invasive surgical procedures.¹ In addition, prostate cancer afflicts 250,000 men in the US each year,² often requiring radical surgical intervention.

Nearly 250,000 surgical procedures for the prostate are performed in the U.S. annually³ to address both benign and malignant conditions, and for patients requiring intervention, post-operative bleeding remains a major complication, resulting in prolonged hospitalization and increased illness and mortality for patients, and increased overall cost of care.

Tricol’s development of an endoluminal hemostatic device, specifically to treat prostatic bleeding, could address a serious unmet need to provide effective bleeding control post-surgery, reduce related morbidity and mortality, and significantly decrease the overall cost of hospitalization.

“Tricol has a long history of developing and commercializing revolutionary hemostatic solutions that save lives,” commented Christopher Rowland, Tricol’s President and CEO.  “The potential for this new application to control bleeding in the surgical realm of prostate procedures could have a significant impact on the health of patients globally.”

For more than 20 years, Tricol has been a world leader in advanced acute wound care innovation and is dedicated to expanding technologies, platforms, and applications to improve and save lives around the globe. Through strong scientific background, a highly skilled team, and significant emphasis on research and development, Tricol has established itself as a global medical products company that continues to innovate its initial foundation of advanced hemostatic solutions. The company holds over 60 patents and 32 clinical publications, manufacturing life-saving hemostatic product families like HemCon^® and OneStop^TM.

Research reported in this publication was supported by the National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health under Award Number R42DK078400. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

1.NeoTract US Market Model estimates for 2020 based on IQVIA™ data.
2.https://www.cancer.org/cancer/prostate-cancer/about/key-statistics.html
3.Urology Care Foundation: 150,000 TURP procedures annually. OncLive:  90,000 radical prostatectomy procedures annually.