The Science Behind Hemostatic Blood Control

Chitosan-based Products

HemCon PRO product application results in rapid adherence to, and sealing of, injured tissue; promotion of clotting independent of the clotting cascade; and demonstrated antibacterial effectiveness within the dressing against a wider range of microorganisms*.

HemCon® PRO products possess hemostatic activity that results from strong polycationic (positive) charge from the incorporated HemCon PRO chitosan. This positive charge correspondingly promotes binding with biopolymers, tissues and cells possessing inherent negative charge. Such negatively charged biopolymers, tissues & cells include other polysaccharides, proteins, oral mucosa, injured tissue surfaces, red blood cells, platelets, bacteria, and viruses.

Behind The M.doc® Products

The m.doc (micro-dispersed oxidized cellulose) HemCon products, unlike our chitosan-based products, work within the clotting cascade.

m.doc activates the intrinsic pathway of the clotting cascade by interacting with individual coagulation enzymes and activating clot formation (specifically FXII). m.doc also activates platelets and forms a soft, gel-like matrix (scab) above the wound which prevents clots from washing away and promotes the clotting process. In addition, it provides a structural scaffold through a gel “plug” formation, which causes physical retardation of blood flow and absorbs fluid and provides a surface for proteins and cells to adhere to and interact with.